BDBM365364 6-amino-N-[bis(3- hydroxypropyl)(oxido)-lambda6- sulfanylidene]-5-(4-{[(3- methylphenyl)carbamoyl]amino} phenyl)pyridine-3- carboxamide::US10633373, Example 69::US10669265, Example 69::US9868726, Example 69

SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)-c2cc(cnc2N)C(=O)N=S(=O)(CCCO)CCCO)c1

InChI Key InChIKey=GKQJWEMAFMQEBO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 365364   

TargetPlatelet-derived growth factor receptor beta(Human)
Allergan

US Patent
LigandPNGBDBM365364(US9868726, Example 69 | 6-amino-N-[bis(3- hydroxyp...)
Affinity DataIC50: 13nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Allergan

US Patent
LigandPNGBDBM365364(US9868726, Example 69 | 6-amino-N-[bis(3- hydroxyp...)
Affinity DataIC50: 83nMAssay Description:Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Allergan

US Patent
LigandPNGBDBM365364(US9868726, Example 69 | 6-amino-N-[bis(3- hydroxyp...)
Affinity DataIC50: 13nMAssay Description:VEGFR2: Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Allergan

US Patent
LigandPNGBDBM365364(US9868726, Example 69 | 6-amino-N-[bis(3- hydroxyp...)
Affinity DataIC50: 83nMAssay Description:PDGFRβ: Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/10/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Allergan

US Patent
LigandPNGBDBM365364(US9868726, Example 69 | 6-amino-N-[bis(3- hydroxyp...)
Affinity DataIC50: 13nMAssay Description:Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg/well of poly-Glu-Tyr (4:1) in 10...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent

TargetPlatelet-derived growth factor receptor beta(Human)
Allergan

US Patent
LigandPNGBDBM365364(US9868726, Example 69 | 6-amino-N-[bis(3- hydroxyp...)
Affinity DataIC50: 83nMAssay Description:Biochemical PDGFRβ kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 μg of poly-Glu-Tyr (4:1) in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details
Go to US Patent