BDBM365121 4-(9-(3-fluoro-4- methoxybenzyl)-8,9- dihydro-7H-6-oxa- 1,2,2a1- triazabenzo[cd]azulen-4- yl)-N-(1-methyl-1H- pyrazol-5-yl)pyrimidin-2- amine::US10278975, Compound I-59 R::US11376260, Example I-59R::US9867833, Compound I-59(R)

SMILES COc1ccc(C[C@@H]2CCOc3cc(cc4nnc2n34)-c2ccnc(Nc3ccnn3C)n2)cc1F

InChI Key InChIKey=WXPNWZWZWVJSGF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365121   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365121(US9867833, Compound I-59(R) | 4-(9-(3-fluoro-4- me...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365121(US9867833, Compound I-59(R) | 4-(9-(3-fluoro-4- me...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 6(Human)
Genentech

US Patent
LigandPNGBDBM365121(US9867833, Compound I-59(R) | 4-(9-(3-fluoro-4- me...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
Go to US Patent