BDBM364979 4-amino-6-{3,4-cis-4-[1-(2-dimethylaminoethyl)-4-(4-fluoro-3-methyl-phenyl)imidazol-2-yl]-3-fluoro-1-piperidyl]}-pyrimidine-5-carbonitrile::US9867826, Compound 9

SMILES CN(C)CCn1cc(nc1[C@@H]1CCN(C[C@@H]1F)c1ncnc(N)c1C#N)-c1ccc(F)c(C)c1

InChI Key InChIKey=OIRFZMZDQYSRGA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 364979   

TargetRibosomal protein S6 kinase beta-1 [T412E](Human)
Merck Patent

US Patent
LigandPNGBDBM364979(US9867826, Compound 9 | 4-amino-6-{3,4-cis-4-[1-(2...)
Affinity DataIC50: 5.5nMAssay Description:P70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components was then added to the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details
Go to US Patent

TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Patent

US Patent
LigandPNGBDBM364979(US9867826, Compound 9 | 4-amino-6-{3,4-cis-4-[1-(2...)
Affinity DataIC50: 5.5nMAssay Description:AKT: A TTP Mosquito liquid handling instrument was used to place 125 nl of the appropriate concentration of inhibitor in 100% DMSO (for a dose respon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2019
Entry Details
Go to US Patent