BDBM36435 (3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthio-methyl-3-hydroxypyrrolidine, 8::CID11404039::DADMe-ImmA-Et

SMILES CCSC[C@H]1CN(Cc2c[nH]c3c(N)ncnc23)C[C@@H]1O

InChI Key InChIKey=OVKULNJFRTYROJ-UHFFFAOYSA-N

Data  1 KI  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 36435   

Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Neisseria meningitidis)
Albert Einstein College of Medicine

LigandPNGBDBM36435(DADMe-ImmA-Et | CID11404039 | (3R,4S)-1-[(9-Deaza-...)
Affinity DataKd:  0.0460nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAminodeoxyfutalosine nucleosidase(Helicobacter pylori (strain ATCC 700392 / 26695) (...)
Albert Einstein College of Medicine

LigandPNGBDBM36435(DADMe-ImmA-Et | CID11404039 | (3R,4S)-1-[(9-Deaza-...)
Affinity DataKd:  0.515nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Klebsiella pneumoniae)
Albert Einstein College of Medicine

LigandPNGBDBM36435(DADMe-ImmA-Et | CID11404039 | (3R,4S)-1-[(9-Deaza-...)
Affinity DataKd:  2.20nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Staphylococcus aureus (Firmicutes))
Albert Einstein College of Medicine

LigandPNGBDBM36435(DADMe-ImmA-Et | CID11404039 | (3R,4S)-1-[(9-Deaza-...)
Affinity DataKd:  1.30nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College of Medicine

LigandPNGBDBM36435(DADMe-ImmA-Et | CID11404039 | (3R,4S)-1-[(9-Deaza-...)
Affinity DataKd:  0.000950nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetAdenosylhomocysteine nucleosidase(Streptococcus pneumoniae)
Albert Einstein College of Medicine

LigandPNGBDBM36435(DADMe-ImmA-Et | CID11404039 | (3R,4S)-1-[(9-Deaza-...)
Affinity DataKd:  10nMpH: 7.5 T: 2°CAssay Description:Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP.More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Target5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase(Escherichia coli (strain K12))
Albert Einstein College of Medicine

LigandPNGBDBM36435(DADMe-ImmA-Et | CID11404039 | (3R,4S)-1-[(9-Deaza-...)
Affinity DataKi:  0.0700nM ΔG°:  -13.8kcal/molepH: 7.5 T: 2°CAssay Description:Purified MTAN activity in MTAN enzyme inhibition assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed