BDBM363436 (S)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(pyridin-3-yl)propanoic acid::US10815208, Example 6::US9850225, Example 2010

SMILES Cc1c(COc2cc(OCc3cncc(c3)C#N)c(CN[C@@H](Cc3cccnc3)C(O)=O)cc2Cl)cccc1-c1ccc2OCCOc2c1

InChI Key InChIKey=PKBSVBJFSCBSOH-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 363436   

TargetProgrammed cell death 1 ligand 1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM363436(US9850225, Example 2010 | (S)-2-((5-chloro-2-((5-c...)
Affinity DataIC50: 50nMAssay Description:The interaction of PD-1 and PD-L1 can be assessed using soluble, purified preparations of the extracellular domains of the two proteins. The PD-1 and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
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TargetProgrammed cell death 1 ligand/protein 1(Human)
Institute of Materia Medica, Chinese Academy of Medical Sciences

US Patent
LigandPNGBDBM363436(US9850225, Example 2010 | (S)-2-((5-chloro-2-((5-c...)
Affinity DataIC50: 35nMAssay Description:1) Principle: PD-1 protein is with HIS tag, and PD-1 ligand PD-L1 is with hFc tag. Eu labeled anti-hFc antibody and XL665 labeled anti-HIS antibody a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
Go to US Patent