BDBM361578 2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(1-((6-(4- chlorophenyl)spiro[3.5]non-6-en-7-yl)methyl)- 1,2,3,6-tetrahydropyridin-4-yl)-N-((3-nitro-4- (((tetrahydro-2H-pyran-4- yl)methyl)amino)phenyl)sulfonyl)benzamide::US10221174, Compound 7::US10829488, Compound 7::US11718613, Compound 9

SMILES [O-][N+](=O)c1cc(ccc1NCC1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)C1=CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1

InChI Key InChIKey=ZGULUKQLEOFSEK-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 361578   

TargetApoptosis regulator Bcl-2(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM361578(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(1-((6-(4...)
Affinity DataIC50: 2.40nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetIsoform Bcl-X(L) of Bcl-2-like protein 1 (Bcl-xL)(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM361578(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(1-((6-(4...)
Affinity DataIC50: 15.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetBcl-2-like protein 11 [72-87](Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM361578(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(1-((6-(4...)
Affinity DataIC50: 2.40nMAssay Description:Bcl-2 and Bcl-xL Inhibition: Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2021
Entry Details
Go to US Patent

TargetBcl-2-like protein 11 [81-106](Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM361578(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(1-((6-(4...)
Affinity DataIC50: 15.7nMAssay Description:Bcl-2 and Bcl-xL Inhibition: Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respect...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/29/2021
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM361578(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(1-((6-(4...)
Affinity DataIC50: 2.40nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM361578(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(1-((6-(4...)
Affinity DataIC50: 15.7nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
Go to US Patent

TargetApoptosis regulator Bcl-2(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM361578(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(1-((6-(4...)
Affinity DataIC50: 1.90nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
Go to US Patent

TargetBcl-2-like protein 1(Human)
The Regents of The University of Michigan

US Patent
LigandPNGBDBM361578(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(1-((6-(4...)
Affinity DataIC50: 20.6nMAssay Description:Fluorescein labeled BIM (81-106), BAK (72-87), and BID (79-99) peptides, named as Flu-BIM, Flu-BAK, and Flu-BID, respectively, were used as the fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/17/2023
Entry Details
Go to US Patent