BDBM361498 N1-(2-fluoro- 4-methoxy-3- ((1R,3R)-3- methyl-2- (2,2,2- trifluoroethyl)- 2,3,4,9- tetrahydro-1H- pyrido[3,4- b]indol-1- yl)phenyl)-N2- (3- fluoropropyl) ethane-1,2- diamine::US10221173, Example 90::US10590132, Example 90::US11046689, Example 90

SMILES COc1ccc(NCCNCCCF)c(F)c1[C@H]1N(CC(F)(F)F)[C@H](C)Cc2c1[nH]c1ccccc21

InChI Key InChIKey=QVJHGBKZCZUPLJ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 361498   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361498(N1-(2-fluoro- 4-methoxy-3- ((1R,3R)-3- methyl-2- (...)
Affinity DataIC50: 0.650nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361498(N1-(2-fluoro- 4-methoxy-3- ((1R,3R)-3- methyl-2- (...)
Affinity DataIC50: 0.300nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM361498(N1-(2-fluoro- 4-methoxy-3- ((1R,3R)-3- methyl-2- (...)
Affinity DataIC50: 5.00E+3nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetEstrogen receptor [307-554](Human)
Astrazeneca

US Patent
LigandPNGBDBM361498(N1-(2-fluoro- 4-methoxy-3- ((1R,3R)-3- methyl-2- (...)
Affinity DataIC50: 0.650nMAssay Description:ERα: The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

LigandPNGBDBM361498(N1-(2-fluoro- 4-methoxy-3- ((1R,3R)-3- methyl-2- (...)
Affinity DataIC50: 5.00E+3nMAssay Description:hERG: The purpose of the hERG binding assay is to evaluate the effects of test compounds on the voltage-dependent potassium channel encoded by the hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361498(N1-(2-fluoro- 4-methoxy-3- ((1R,3R)-3- methyl-2- (...)
Affinity DataIC50: 0.650nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

LigandPNGBDBM361498(N1-(2-fluoro- 4-methoxy-3- ((1R,3R)-3- methyl-2- (...)
Affinity DataIC50: 5.00E+3nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent