BDBM361497 3-((1R,3R)-1- (2,6-difluoro- 3-((2-((3- fluoropropyl) amino)ethyl) amino)phenyl)-6- fluoro-3- methyl- 1,3,4,9- tetrahydro-2H- pyrido[3,4- b]indol-2-yl)- 2,2- difluoropropan- 1-ol::US10221173, Example 89::US10590132, Example 89::US11046689, Example 89

SMILES C[C@@H]1Cc2c([nH]c3ccc(F)cc23)[C@H](N1CC(F)(F)CO)c1c(F)ccc(NCCNCCCF)c1F

InChI Key InChIKey=OBXCEMCJDFYPCO-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 361497   

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361497(3-((1R,3R)-1- (2,6-difluoro- 3-((2-((3- fluoroprop...)
Affinity DataIC50: 0.910nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
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TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361497(3-((1R,3R)-1- (2,6-difluoro- 3-((2-((3- fluoroprop...)
Affinity DataIC50: 0.140nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

LigandPNGBDBM361497(3-((1R,3R)-1- (2,6-difluoro- 3-((2-((3- fluoroprop...)
Affinity DataIC50: 6.10E+3nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2019
Entry Details
Go to US Patent

TargetEstrogen receptor [307-554](Human)
Astrazeneca

US Patent
LigandPNGBDBM361497(3-((1R,3R)-1- (2,6-difluoro- 3-((2-((3- fluoroprop...)
Affinity DataIC50: 0.910nMAssay Description:ERα: The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

LigandPNGBDBM361497(3-((1R,3R)-1- (2,6-difluoro- 3-((2-((3- fluoroprop...)
Affinity DataIC50: 6.10E+3nMAssay Description:hERG: The purpose of the hERG binding assay is to evaluate the effects of test compounds on the voltage-dependent potassium channel encoded by the hu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

US Patent
LigandPNGBDBM361497(3-((1R,3R)-1- (2,6-difluoro- 3-((2-((3- fluoroprop...)
Affinity DataIC50: 0.910nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent

LigandPNGBDBM361497(3-((1R,3R)-1- (2,6-difluoro- 3-((2-((3- fluoroprop...)
Affinity DataIC50: 6.10E+3nMAssay Description:hERG (human ether a go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2021
Entry Details
Go to US Patent