BDBM358860 N-[3-(dimethylamino)propyl]-3-[4-(morpholin-4-yl)furo[3,2-c]pyridin-2-yl]-imidazo[1,2-b]pyridazine-6-carboxamide::US10214545, Example 9

SMILES CN(C)CCCNC(=O)c1ccc2ncc(-c3cc4c(nccc4o3)N3CCOCC3)n2n1

InChI Key InChIKey=XANSVPHMOYWUDL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 358860   

TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358860(N-[3-(dimethylamino)propyl]-3-[4-(morpholin-4-yl)f...)
Affinity DataIC50: 1.5nMAssay Description:MKNK1-inhibitory activity of compounds of the present invention was quantified employing the MKNK1 TR-FRET assay as described in the following paragr...More data for this Ligand-Target Pair
In DepthDetails
US Patent

TargetIsoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 (MNK1a)(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM358860(N-[3-(dimethylamino)propyl]-3-[4-(morpholin-4-yl)f...)
Affinity DataIC50: 4.5nMAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
In DepthDetails
US Patent