BDBM357651 7-(2- fluorobenzyl)- 3H- [1,2,3]triazolo [4,5-b]pyridin- 5-amine::US10214527, Example 23

SMILES Nc1cc(Cc2ccccc2F)c2nn[nH]c2n1

InChI Key InChIKey=WSDHKYHHPHTISH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 357651   

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357651(US10214527, Example 23 | 7-(2- fluorobenzyl)- 3H- ...)
Affinity DataIC50: 55nMAssay Description:MPO peroxidation activity was measured in 100 mM KPi (pH 7.4) by utilizing the non-fluorescent reagent Amplex Red (Invitrogen catalog # A12222) which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357651(US10214527, Example 23 | 7-(2- fluorobenzyl)- 3H- ...)
Affinity DataIC50: 32nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 240 mM NaCl and 10 uM H2O2 by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetMyeloperoxidase(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM357651(US10214527, Example 23 | 7-(2- fluorobenzyl)- 3H- ...)
Affinity DataIC50: 46nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins by amplex red dye based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed