BDBM356714 1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypropyl)-5- methylpyrrolidin-2- one::US10214507, Compound 34::US10759777, Compound 34

SMILES CC1CCC(=O)N1CC(O)Cn1c2ccc(F)cc2c2cc(F)ccc12

InChI Key InChIKey=PFDBNPNOCYZVAO-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 356714   

TargetPeriod circadian protein homolog 2(Human)
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US Patent
LigandPNGBDBM356714(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Affinity DataEC50:  286nMAssay Description:Compounds were screened by using a high-throughput circadian assay system as previously described in Zhang, E. E. et al. Cell, 2009, 139, 199-210. In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
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TargetCryptochrome-2(Human)TBA
LigandPNGBDBM356714(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Affinity DataEC50:  199nMAssay Description:Modulation activity at CRY2/PER2 in human U2OS cells harboring per2-dLuc assessed as activation of per2 activity measured every 100 mins for 5 days b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetPeriod circadian protein homolog 2(Human)
Reset Therapeutics

US Patent
LigandPNGBDBM356714(1-(3-(3,6-difluoro- 9H-carbazol-9-yl)-2- hydroxypr...)
Affinity DataEC50:  286nMAssay Description:In brief, stable U20S reporter cells harboring Per2-dLuc were plated at a density of 30,000 cells/well in Corning 96-well, solid white, flat bottom, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent