BDBM35617 5-chloroindolecarboxamide, 2a

SMILES OCc1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1

InChI Key InChIKey=AXRLHHFRSCCWLI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 35617   

TargetGlycogen phosphorylase, liver form(Human)
Astellas Pharma

LigandPNGBDBM35617(5-chloroindolecarboxamide, 2a)
Affinity DataIC50: 1.60E+3nMpH: 6.8 T: 2°CAssay Description:The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2009
Entry Details Article
PubMed
TargetNa(+)/H(+) exchange regulatory cofactor NHE-RF1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM35617(5-chloroindolecarboxamide, 2a)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetNa(+)/H(+) exchange regulatory cofactor NHE-RF1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM35617(5-chloroindolecarboxamide, 2a)
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of NHERF1 in human Ls174T cells stably transfected with Dox-inducible shRNA for beta-catenin (Ls174Tsh-beta-Cat) assessed as inhibition of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed