BDBM356151 N-(6-acetyl-2-phenyl-5,6,7,8- tetrahydro-1,6-naphthyridin-3- yl)-2-chloro-5-(1-methyl-1H- pyrazol-3-yl)-4- (trifluoromethyl)benzamide::US9815846, Compound 151

SMILES CC(=O)N1CCc2nc(c(NC(=O)c3cc(-c4ccn(C)n4)c(cc3Cl)C(F)(F)F)cc2C1)-c1ccccc1

InChI Key InChIKey=SVGYKYVOBLISPM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 356151   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM356151(US9815846, Compound 151 | N-(6-acetyl-2-phenyl-5,6...)
Affinity DataIC50: 0.540nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
Go to US Patent