BDBM355886 (S)-1-(5-chloro-6- (2H-1,2,3-triazol-2- yl)pyridin-3-yl)-3-(2- chloro-7-(1- methoxyethyl)pyrazo- lo[1,5-a]pyrimidin-6- yl)urea::US10442808, Example 10::US9815842, Example 10

SMILES CO[C@@H](C)c1c(NC(=O)Nc2cnc(c(Cl)c2)-n2nccn2)cnc2cc(Cl)nn12

InChI Key InChIKey=GBIASRXDYFFUED-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 355886   

LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 30nMAssay Description:Inhibition of MALT1 in human OCILY3 cells assessed as reduction in BCL10 cleavage by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 6nMAssay Description:Inhibition of MALT1 (unknown origin) by Glosensor reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCathepsin S(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of cathepsin S (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of cathepsin L (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCathepsin K(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of cathepsin K (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetDipeptidyl peptidase 1(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of cathepsin C (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCathepsin B(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of cathepsin B (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCaspase-3(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of caspase-3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 0.00200nMAssay Description:IC50 values of test compounds were determined with an enzyme activity assay using the C-domain of MALT1 (amino acids 329-824). The readout parameter ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2019
Entry Details
Go to US Patent

LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 40nMAssay Description:Inhibition of MALT1 in human OCILY3 cells by NF-kappaB reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 500nMAssay Description:Inhibition of MALT1 in human whole blood assessed as reduction in PMA//anti-CD28 antibody-induced IL2 level pre-incubated for 1 hrs before stimulatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 20nMAssay Description:Inhibition of MALT1 in PMA-stimulated human Jurkat T cells assessed as reduction in IL2 level pretreated for 30 mins followed by PMA-stimulation meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 3nMAssay Description:Inhibition of MALT1 (unknown origin) using Ac-Trp-Leu-Arg-Ser-Arg^Cys(PT14)-NH2 as substrate preincubated for 60 mins followed by substrate addition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM355886(US9815842, Example 10 | (S)-1-(5-chloro-6- (2H-1,2...)
Affinity DataIC50: 0.00200nMAssay Description:The assay employs a short peptide substrate labeled with the single fluorophore PT14 as a fluorescence lifetime probe sensitive to the cleavage state...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details
Go to US Patent