BDBM35587 pyrazolo pyrimidine, 19

SMILES COC(=O)Nc1ccc(cc1)-c1nc(N2CCOCC2)c2cnn(C3CCN(CC3)C(=O)OC)c2n1

InChI Key InChIKey=IMXHGCRIEAKIBU-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 35587   

TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35587(pyrazolo pyrimidine, 19)
Affinity DataIC50: 4.30nMpH: 7.4 T: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
LigandPNGBDBM35587(pyrazolo pyrimidine, 19)
Affinity DataIC50: 1.03E+3nMT: 2°CAssay Description:The enzyme was assayed in DELFIA format using purified FLAG-TOR in kinase buffer containing ATP and His6-S6K in the presence of inhibitor compounds. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
LigandPNGBDBM35587(pyrazolo pyrimidine, 19)
Affinity DataIC50: 1.03E+3nMAssay Description:Inhibition of p100alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35587(pyrazolo pyrimidine, 19)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant mTOR assessed as inhibition of S6K T389 phosphorylation by DELFIA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetTarget of rapamycin complex 2 subunit MAPKAP1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM35587(pyrazolo pyrimidine, 19)
Affinity DataIC50: 5nMAssay Description:Inhibition of mTORC2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetTarget of rapamycin complex subunit LST8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM35587(pyrazolo pyrimidine, 19)
Affinity DataIC50: 5nMAssay Description:Inhibition of mTORC1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Wyeth Research

LigandPNGBDBM35587(pyrazolo pyrimidine, 19)
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant FLAG-tagged mTOR (unknown origin) expressed in HEK293 cells assessed as decrease in phosphorylation of S6K level at Thr389 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed