BDBM35554 thiophene scaffold, 21

SMILES CC(C)N(C(=O)[C@H]1CC[C@H](C)CC1)c1cc(sc1C(O)=O)-c1ccccc1

InChI Key InChIKey=RZXQBIKGWSLVEK-UHFFFAOYSA-N

Data  8 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 35554   

TargetGenome polyprotein(HCV)
Irbm, Mrl Rome

LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataIC50: 100nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataIC50: 500nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Irbm, Mrl Rome

LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataIC50: 1.00E+4nMAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2009
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataKd:  427nMAssay Description:Inhibition of HCV NS5B polymerase L419M mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepacivirus C)
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataKd:  33nMAssay Description:Inhibition of HCV NS5B polymerase M414T mutantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Idenix Sarl, An Msd

Curated by ChEMBL
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of HCV NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetGenome polyprotein(HCV)
Idenix Sarl, An Msd

Curated by ChEMBL
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataIC50: 35nMAssay Description:Inhibition of HCV genotype 1b J4 NS5B RNA dependent RNA polymeraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed