BDBM354872 Preparation of 4-{5-[4-(piperazine-1-carbonyl)-phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}-benzamide, hydrochloride salt::US10485800, Example 149::US9814704, Example 149

SMILES NC(=O)c1ccc(cc1)-c1c[nH]c2ncc(cc12)-c1ccc(cc1)C(=O)N1CC[NH2+]CC1

InChI Key InChIKey=KGRHWBRNFKQGRZ-UHFFFAOYSA-O

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 354872   

TargetMitogen-activated protein kinase kinase kinase 11(Human)
The University of Rochester

US Patent
LigandPNGBDBM354872(US9814704, Example 149 | Preparation of 4-{5-[4-(p...)
Affinity DataIC50: 100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2019
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 11(Human)
The University of Rochester

US Patent
LigandPNGBDBM354872(US9814704, Example 149 | Preparation of 4-{5-[4-(p...)
Affinity DataIC50: 100nMAssay Description:200 ng (130 nM) MLK3 (Dundee, DU8313) was incubated with 1 μM inactive MKK7b (Dundee, DU703) in the presence of 2 μM cold ATP (Km) and 0.5 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
Go to US Patent