BDBM354126 US9796708, Example 1358::trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-2-yl]-3,6-dihydropyridin-1(2H)-yl})cyclohexanecarboxylic acid

SMILES COc1ccc(F)cc1-c1c(F)cnc2[nH]c(cc12)C1=CCN(CC1)[C@H]1CC[C@@H](CC1)C(O)=O

InChI Key InChIKey=RYPUWZOEFAAXRB-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 354126   

TargetCyclin-dependent kinase 9(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 78nMAssay Description:Inhibition of CDK9 (unknown origin) using Ulight-labeled substrate measured after 1.5 hrs by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 8(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of CDK8 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 1.44E+4nMAssay Description:Inhibition of CDK7 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 6(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 101nMAssay Description:Inhibition of CDK6 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 16nMAssay Description:Inhibition of CDK4 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 328nMAssay Description:Inhibition of CDK2 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 348nMAssay Description:Inhibition of CDK1 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of CDK9 (unknown origin) by LANCE ULight TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 110nMAssay Description:Inhibition of CDK9 in human A-431 cells assessed as reduction in RNA polymerase2 phosphorylation at C-terminal ser2 residue incubated for 4 hrs by In...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Abbvie

US Patent
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 82nMAssay Description:CDK9 enzyme activities were measured using LANCE ULight TR-FRET kinase assay reagents (PerkinElmer, Waltham, Mass.). Compounds were directly added in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 8(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 320nMAssay Description:Inhibition of CDK8 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 7(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 320nMAssay Description:Inhibition of CDK7 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 320nMAssay Description:Inhibition of CDK2 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 1(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 320nMAssay Description:Inhibition of CDK1 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 6(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 101nMAssay Description:Inhibition of CDK6 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 4(Human)
Nankai University

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 162nMAssay Description:Inhibition of CDK4 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Abbvie

Curated by ChEMBL
LigandPNGBDBM354126(trans-4-{4-[5-fluoro-4-(5-fluoro-2-methoxyphenyl)-...)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of CDK9 (unknown origin) using Ulight-labeled substrate by TR-FRET LANCE methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed