BDBM35401 3-hydroxy-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one::3-hydroxy-2-phenyl-3,5-dihydro-2H-1,5-benzothiazepin-4-one::3-oxidanyl-2-phenyl-3,5-dihydro-2H-1,5-benzothiazepin-4-one::MLS000045785::SMR000028182::cid_3242458

SMILES OC1C(Sc2ccccc2NC1=O)c1ccccc1

InChI Key InChIKey=ZUOHMTWRFCETKE-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 35401   

TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 2.01E+4nMpH: 7.0 T: 2°CAssay Description:The MKP-1 HTS confirmation dose response assay has been developed to confirm actives identified in the MH-76391 In vitro HTS assay for MKP-1 inhibito...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2009
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 3.55E+4nMAssay Description:The MKP-1 dose response Active/Probe assessment-DTT assay has been developed to evaluate the effects of increased DTT concentration on the MKP-1 inhi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 3.55E+4nMAssay Description:The MKP-1 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 1(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 3.32E+4nMAssay Description:The MKP-1 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-1 inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 6(Rat)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 5.00E+4nMAssay Description:The in vitro MKP-3 Phosphatase dose response hit/probe assessment assay has been developed and run at the University of Pittsburgh Molecular Screenin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2011
Entry Details
PCBioAssay
TargetEstrogen receptor(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 3.02E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/6/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 6(Rat)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 5.00E+4nMAssay Description:The MKP-3 dose response Active/Probe assessment-Catalase assay has been developed to evaluate the effects of adding 100 U/mL of Catalase on the MKP-3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 6(Rat)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 5.00E+4nMAssay Description:The MKP-3 dose response assay Active/Probe Assessment Assay - Reproducibility testing has been developed to test the reproducibility of MKP-3 inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetM-phase inducer phosphatase 2(Human)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 5.00E+4nMAssay Description:The MKP-1 Dual Specificity Protein Tyrosine Phosphatase Probe Assessment Cdc25B Dose Response Selectivity Assay has been developed to evaluate the PT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 3.54E+4nMAssay Description:Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation NIH Molecular Libraries Screening Centers Network [MLSC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay
TargetEstrogen receptor beta(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 161nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay
TargetEstrogen receptor beta(Human)
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 1.56E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2011
Entry Details
PCBioAssay
TargetTyrosine-protein phosphatase non-receptor type 7(Human)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 1.15E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2011
Entry Details
PCBioAssay
TargetDual specificity protein phosphatase 6(Rat)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2011
Entry Details
PCBioAssay
TargetCore protein(Hepacivirus C)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 4.98E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute, TSRI Assay Provide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
LigandPNGBDBM35401(SMR000028182 | 3-hydroxy-2-phenyl-2,3-dihydro-1,5-...)
Affinity DataIC50: 5.33E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2012
Entry Details
PCBioAssay