BDBM352283 (E)-3-(5-Chloro-2-tetrazol-1-yl-phenyl)-N—((S)-9-oxo-19-oxa-8,17,18-triaza-tricyclo[14.2.1.02,7]nonadeca-1(18),2,4,6,12,16-hexaen-15-yl)-acrylamide, and (Z)-3-(5-Chloro-2-tetrazol-1-yl-phenyl)-N—((S)-9-oxo-19-oxa-8,17,18-triaza-tricyclo[14.2.1.02,7]nonadeca-1(18),2,4,6,12,16-hexaen-15-yl)-acrylamide::US10487086, Example 122::US11136327, Example 122::US9802939, 122

SMILES Clc1ccc(c(\C=C\C(=O)N[C@H]2CC=CCCC(=O)Nc3ccccc3-c3nnc2o3)c1)-n1cnnn1

InChI Key InChIKey=SPUGCRWFPANOPP-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 352283   

TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM352283(US9802939, 122 | (E)-3-(5-Chloro-2-tetrazol-1-yl-p...)
Affinity DataKi:  25nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM352283(US9802939, 122 | (E)-3-(5-Chloro-2-tetrazol-1-yl-p...)
Affinity DataKi:  25nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of the coagulation Factors XIa, VIIa, IXa, Xa, XIIa, plasma kallikrein or throm...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2020
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM352283(US9802939, 122 | (E)-3-(5-Chloro-2-tetrazol-1-yl-p...)
Affinity DataKi:  25nMAssay Description:Factor XIa determinations were made in 50 mM HEPES buffer at pH 7.4 containing 145 mM NaCl, 5 mM KCl, and 0.1% PEG 8000 (polyethylene glycol; JT Bake...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2022
Entry Details
Go to US Patent