BDBM35192 pyrimidoindolone, 11a

SMILES CC1(C)CN=C2N(C1)c1ccc(cc1C2=O)S(=O)(=O)N1CCC[C@H]1COc1ccc(F)cc1

InChI Key InChIKey=GJHKJQCTYJSQIH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 35192   

TargetCaspase-3(Human)
Wyeth Research

LigandPNGBDBM35192(pyrimidoindolone, 11a)
Affinity DataIC50: 10.8nMpH: 7.2 T: 2°CAssay Description:Caspase-3 was assayed at 23 deg C (room temp) in 96-well plates using the internally quenched tetrapeptide substrate. Enzymatic cleavage between the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2009
Entry Details Article
PubMed