BDBM350282 US10208064, Example 2

SMILES CC1=C(COC1=O)N1CCC2(CCN(C[C@@H](O)c3ccc-4c(Cn5nnnc-45)c3Cl)CC2)C1=O

InChI Key InChIKey=ISFIRMKOWDAWGE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 350282   

TargetATP-sensitive inward rectifier potassium channel 1(Human)
Wuxi Apptec (Shanghai)

US Patent
LigandPNGBDBM350282(US10208064, Example 2)
Affinity DataIC50: 9nMAssay Description:A Thallium Flux Assay was performed on the compounds of the Examples. This assay has been described previously; see, e.g., PCT Published Application ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetATP-sensitive inward rectifier potassium channel 1(Rat)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM350282(US10208064, Example 2)
Affinity DataIC50: 9nMAssay Description:Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/18/2021
Entry Details Article
PubMed