BDBM350111 N-(3-(1H-1,2,4-triazol-3- ylthio)-4- hydroxynaphthalen-1-yl)- 2,4,5-trimethyl- benzenesulfonamide::US10208043, # 12::US10941146, # 12

SMILES Cc1cc(C)c(cc1C)S(=O)(=O)Nc1cc(Sc2nc[nH]n2)c(O)c2ccccc12

InChI Key InChIKey=OSWBIEMETBPYGH-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 350111   

TargetFascin(Human)
Cornell University

US Patent
LigandPNGBDBM350111(US10208043, # 12 | N-(3-(1H-1,2,4-triazol-3- ylthi...)
Affinity DataIC50: 539nMAssay Description:About 150,000 compounds were screened. These chemical compounds were from the LOPAC 1280 collection, the Prestwick chemical library, the Pharmakon co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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TargetNuclear factor erythroid 2-related factor 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM350111(US10208043, # 12 | N-(3-(1H-1,2,4-triazol-3- ylthi...)
Affinity DataKd:  3.60E+3nMAssay Description:Inhibition of Keap1-Nrf2 (unknown origin) interaction assessed as compound's equilibrium dissociation constant after 60 mins by fluorescence anisotro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2020
Entry Details Article
PubMed
TargetFascin(Human)
Cornell University

US Patent
LigandPNGBDBM350111(US10208043, # 12 | N-(3-(1H-1,2,4-triazol-3- ylthi...)
Affinity DataIC50: 539nMAssay Description:A high throughput assay was developed to screen for fascin specific inhibitors. Purified polymerized F-actin with or without fascin were mixed and in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/20/2021
Entry Details
Go to US Patent