BDBM350075 6-(3-amino-6-(1- cyclopropyl-1H-pyrazol- 4-yl)pyrazin-2-yl)-2-(2,6- dichloro-3,5- dimethoxyphenyl)pyridazin- 3(2H)-one::US10208024, Example 74::US10766881, Example 74

SMILES COc1cc(OC)c(Cl)c(c1Cl)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C1CC1

InChI Key InChIKey=ADXIYSMNFMHFLE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350075   

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM350075(6-(3-amino-6-(1- cyclopropyl-1H-pyrazol- 4-yl)pyra...)
Affinity DataIC50: 5.80nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen Assay technology which directly measures the amount of substrate phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM350075(6-(3-amino-6-(1- cyclopropyl-1H-pyrazol- 4-yl)pyra...)
Affinity DataIC50: 9.5nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen Assay technology which directly measures the amount of substrate phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM350075(6-(3-amino-6-(1- cyclopropyl-1H-pyrazol- 4-yl)pyra...)
Affinity DataIC50: 6.10nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen Assay technology which directly measures the amount of substrate phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1 [308-731](Human)
Array Biopharma

US Patent
LigandPNGBDBM350075(6-(3-amino-6-(1- cyclopropyl-1H-pyrazol- 4-yl)pyra...)
Affinity DataIC50: 5.80nMAssay Description:To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2 [403-822](Human)
Array Biopharma

US Patent
LigandPNGBDBM350075(6-(3-amino-6-(1- cyclopropyl-1H-pyrazol- 4-yl)pyra...)
Affinity DataIC50: 9.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3 [397-806](Human)
Array Biopharma

US Patent
LigandPNGBDBM350075(6-(3-amino-6-(1- cyclopropyl-1H-pyrazol- 4-yl)pyra...)
Affinity DataIC50: 6.10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent