BDBM350008 6-(3-amino-6-(1-(1- hydroxy-2- methylpropan-2-yl)- 1H-pyrazol-4- yl)pyrazin-2-yl)-2- (3,5-dimethoxyphenyl) pyridazin-3(2H)-one::US10208024, Example 7::US10766881, Example 7

SMILES COc1cc(OC)cc(c1)-n1nc(ccc1=O)-c1nc(cnc1N)-c1cnn(c1)C(C)(C)CO

InChI Key InChIKey=WEYMBVBPABXYAP-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 350008   

TargetFibroblast growth factor receptor 1(Human)
Array Biopharma

US Patent
LigandPNGBDBM350008(6-(3-amino-6-(1-(1- hydroxy-2- methylpropan-2-yl)-...)
Affinity DataIC50: 14.5nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen Assay technology which directly measures the amount of substrate phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
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TargetFibroblast growth factor receptor 2(Human)
Array Biopharma

US Patent
LigandPNGBDBM350008(6-(3-amino-6-(1-(1- hydroxy-2- methylpropan-2-yl)-...)
Affinity DataIC50: 6.5nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen Assay technology which directly measures the amount of substrate phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3(Human)
Array Biopharma

US Patent
LigandPNGBDBM350008(6-(3-amino-6-(1-(1- hydroxy-2- methylpropan-2-yl)-...)
Affinity DataIC50: 10.7nMAssay Description:FGFR1, 2 and 3 kinase activity was measured by the Invitrogen LanthaScreen Assay technology which directly measures the amount of substrate phosphory...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 1 [308-731](Human)
Array Biopharma

US Patent
LigandPNGBDBM350008(6-(3-amino-6-(1-(1- hydroxy-2- methylpropan-2-yl)-...)
Affinity DataIC50: 14.5nMAssay Description:To measure FGFR1 kinase activity, 200 pM His-tagged recombinant human FGFR1 catalytic domain (amino acids 308-731) (Life Technologies Cat. No. PR4660...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 2 [403-822](Human)
Array Biopharma

US Patent
LigandPNGBDBM350008(6-(3-amino-6-(1-(1- hydroxy-2- methylpropan-2-yl)-...)
Affinity DataIC50: 6.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 3 [397-806](Human)
Array Biopharma

US Patent
LigandPNGBDBM350008(6-(3-amino-6-(1-(1- hydroxy-2- methylpropan-2-yl)-...)
Affinity DataIC50: 10.7nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent