BDBM349547 US10207991, Ex. Cpd. No. 62::US10611728, Example Compound 62::US11691947, Example 62

SMILES CC(C)(C)Oc1cc(CCC(C)(C)N2Cc3ccc(cc3C2)S(C)(=O)=O)ccc1O

InChI Key InChIKey=ISQAPFMBJFZOLG-UHFFFAOYSA-N

Data  13 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 349547   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataIC50: 2.60E+4nMAssay Description:Representative sigma-2 antagonists test compounds do not induce neuronal or glial toxicity with acute or chronic dosing in vitro. The sigma-2 recepto...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Cognition Therapeutics

US Patent
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataEC50:  2.60E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells measured by Patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-1,3-di-O-tolylguanidine from human sigma 2 receptor/TMEM97 transfected in sigma 1 receptor knockout HEK293 cell membranes assess...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  8nMAssay Description:Binding affinity to sigma2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  8.5nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  8.5nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  8.5nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetSigma intracellular receptor 2(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  8.5nMAssay Description:Binding affinity to Sigma 2-receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetSigma intracellular receptor 2(Rat)
Cognition Therapeutics

US Patent
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  8.5nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]-(+)-pentazocine from human sigma1 receptor transfected in HEK293 cell membranes assessed as inhibition constant incubated for 12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  63nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/21/2019
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  63nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2019
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  63nMAssay Description:Radioligand binding assays for Sigma-1 receptors and Sigma-2 receptors were carried out by a commercial contract research organization. For Sigma-1 b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2020
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Cognition Therapeutics

US Patent
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  63nMAssay Description:The affinity of candidate sigma-2 ligand compounds at sigma-1 and sigma-2 receptors was also determined by displacement of different known labeled si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2023
Entry Details
Go to US Patent

TargetSigma non-opioid intracellular receptor 1(Human)
Welab Barcelona

Curated by ChEMBL
LigandPNGBDBM349547(US10207991, Ex. Cpd. No. 62 | US10611728, Example ...)
Affinity DataKi:  63nMAssay Description:Binding affinity to sigma1 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed