BDBM347356 N-(3-(2H-tetrazol-5-yl)-5-(trifluoromethyl)phenyl)-2-(4-(5-ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)acetamide::US9789100, Example 44

SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(cc(c2)C(F)(F)F)-c2nn[nH]n2)c(F)c1

InChI Key InChIKey=IAEIUPIKHORLLT-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 347356   

TargetProto-oncogene tyrosine-protein kinase receptor Ret [658-1114](Human)
Glaxosmithkline

US Patent

LigandBDBM347356(N-(3-(2H-tetrazol-5-yl)-5-(trifluoromethyl)phenyl)...)Copy SMILESCopy InChI

Affinity DataIC50: 100nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/9/2019
Entry Details
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