BDBM347341 2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fluorophenyl)-N-(3-(5-methyl-1,3,4-oxadiazol-2-yl)-5-(trifluoromethyl)phenyl)acetamide::US9789100, Example 29

SMILES CCOc1cc(c[nH]c1=O)-c1ccc(CC(=O)Nc2cc(cc(c2)C(F)(F)F)-c2nnc(C)o2)c(F)c1

InChI Key InChIKey=UQWLZLVHLBFFHI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 347341   

LigandPNGBDBM347341(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataIC50: 100nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

LigandPNGBDBM347341(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataIC50: 100nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent

LigandPNGBDBM347341(2-(4-(4-Ethoxy-6-oxo-1,6-dihydropyridin-3-yl)-2-fl...)
Affinity DataIC50: 100nMAssay Description:Human RET kinase cytoplasmic domain (amino acids 658-1114 of accession number NP_000314.1) was expressed as an N-terminal GST-fusion protein using a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/9/2019
Entry Details
Go to US Patent