BDBM346501 8-quinolylmethyl 4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-2,6-dimethyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-3-carboxylate::US10202378, Example 105

SMILES Cc1[nH]c2c(c1C(=O)OCc1cccc3cccnc13)c(cn(C)c2=O)C#CC(C)(O)C1CC1

InChI Key InChIKey=NSWCLFHDBPRJST-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 346501   

LigandPNGBDBM346501(8-quinolylmethyl 4-(3-cyclopropyl-3-hydroxy-but-1-...)
Affinity DataIC50: 34.6nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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LigandPNGBDBM346501(8-quinolylmethyl 4-(3-cyclopropyl-3-hydroxy-but-1-...)
Affinity DataIC50: 93.9nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent