BDBM346492 3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-2,6-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-one::US10202378, Example 187::US10202378, Example 98a::US10202378, Example 98b

SMILES Cc1[nH]c2c(c1-c1nnc(o1)C(C)(C)C)c(cn(C)c2=O)C#CC(C)(O)C1CC1

InChI Key InChIKey=OZWRPGVUTGFIAO-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 346492   

LigandPNGBDBM346492(US10202378, Example 98a | US10202378, Example 98b ...)
Affinity DataIC50: 58nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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LigandPNGBDBM346492(US10202378, Example 98a | US10202378, Example 98b ...)
Affinity DataIC50: 216nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
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LigandPNGBDBM346492(US10202378, Example 98a | US10202378, Example 98b ...)
Affinity DataIC50: 227nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

LigandPNGBDBM346492(US10202378, Example 98a | US10202378, Example 98b ...)
Affinity DataIC50: 728nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

LigandPNGBDBM346492(US10202378, Example 98a | US10202378, Example 98b ...)
Affinity DataIC50: 33.9nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

LigandPNGBDBM346492(US10202378, Example 98a | US10202378, Example 98b ...)
Affinity DataIC50: 108nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent