BDBM346460 US10202378, Example 73::US10202378, Example 91a::US10202378, Example 91b::ethyl 2,6-dimethyl-7-oxo-4-(4,4,4-trifluoro-3-hydroxy-3-phenyl-but-1-ynyl)-1H-pyrrolo[2,3-c]pyridine-3-carboxylate

SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1ccccc1)C(F)(F)F

InChI Key InChIKey=NFNLYRHIYRUYNX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 346460   

LigandPNGBDBM346460(US10202378, Example 73 | US10202378, Example 91b |...)
Affinity DataIC50: 69.5nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

LigandPNGBDBM346460(US10202378, Example 73 | US10202378, Example 91b |...)
Affinity DataIC50: 287nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

LigandPNGBDBM346460(US10202378, Example 73 | US10202378, Example 91b |...)
Affinity DataIC50: 206nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

LigandPNGBDBM346460(US10202378, Example 73 | US10202378, Example 91b |...)
Affinity DataIC50: 749nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

LigandPNGBDBM346460(US10202378, Example 73 | US10202378, Example 91b |...)
Affinity DataIC50: 42.2nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

LigandPNGBDBM346460(US10202378, Example 73 | US10202378, Example 91b |...)
Affinity DataIC50: 184nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent