BDBM346428 US10202378, Example 41::ethyl 2,6-dimethyl-7-oxo-4-[4,4,4-trifluoro-3-hydroxy-3-[3-(1H-pyrazol-4-yl)phenyl]but-1-ynyl]-1H-pyrrolo[2,3-c]pyridine-3-carboxylate

SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(O)(c1cccc(c1)-c1cn[nH]c1)C(F)(F)F

InChI Key InChIKey=XAUCGYGBYUPKFL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 346428   

LigandPNGBDBM346428(ethyl 2,6-dimethyl-7-oxo-4-[4,4,4-trifluoro-3-hydr...)
Affinity DataIC50: 21.5nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent

LigandPNGBDBM346428(ethyl 2,6-dimethyl-7-oxo-4-[4,4,4-trifluoro-3-hydr...)
Affinity DataIC50: 171nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2019
Entry Details
Go to US Patent