BDBM3451 3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diethylamino)butyl]amino}pyrido[2,3-d]pyrimidin-7-yl]urea::6-arylpyrido[2,3-d]pyrimidine deriv. 33::CHEMBL45827

SMILES CCN(CC)CCCCNc1ncc2cc(c(NC(=O)NC(C)(C)C)nc2n1)-c1c(Cl)cccc1Cl

InChI Key InChIKey=MKVMEJKNLUWFSQ-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 3451   

LigandPNGBDBM3451(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)
Affinity DataIC50: 360nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM3451(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)
Affinity DataIC50: 48nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM3451(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)
Affinity DataIC50: 7.40nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3451(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of insulin receptor (InsR) tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3451(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)
Affinity DataIC50: 240nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr) tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM3451(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)
Affinity DataIC50: 44nMAssay Description:Inhibition of C-src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM3451(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)
Affinity DataIC50: 23nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3451(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)
Affinity DataIC50: 390nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM3451(3-tert-butyl-1-[6-(2,6-dichlorophenyl)-2-{[4-(diet...)
Affinity DataIC50: 360nMAssay Description:Inhibitory concentration of compound against mouse Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed