BDBM3443 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea::6-arylpyrido[2,3-d]pyrimidine deriv. 25::CHEMBL299763::PD 166866::PD166866

SMILES COc1cc(OC)cc(c1)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C

InChI Key InChIKey=NHJSWORVNIOXIT-UHFFFAOYSA-N

Data  1 KI  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 3443   

TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr) tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetMitogen-activated protein kinase 1/3(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article

TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article

TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article

TargetInsulin receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article

TargetCyclin-dependent kinase 4(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 4.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article

TargetProto-oncogene tyrosine-protein kinase Src(Chicken)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of chicken c-Src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory concentration of compound against mouse Platelet-derived growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of C-src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetInsulin receptor(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of insulin receptor (InsR) tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article

TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 60nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataIC50: 48nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3443(6-arylpyrido[2,3-d]pyrimidine deriv. 25 | PD 16686...)
Affinity DataKi:  45.2nMMore data for this Ligand-Target Pair
In DepthDetails
PubMed