BDBM3441 1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea::6-arylpyrido[2,3-d]pyrimidine deriv. 23::CHEMBL56236::PD162628

SMILES Cc1cc(C)c(C)c(c1C)-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C

InChI Key InChIKey=NNYHIJGVHOAIGK-UHFFFAOYSA-N

Data  15 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 3441   

LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 710nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2005
Entry Details Article
PubMed
LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 710nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetInsulin receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of insulin receptor (InsR) tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 6.68E+3nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr) tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of C-src tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 6.68E+3nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetInsulin receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetCyclin-dependent kinase 4(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 4.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article

TargetMitogen-activated protein kinase 1/3(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3441(1-[2-amino-6-(2,3,5,6-tetramethylphenyl)pyrido[2,3...)
Affinity DataIC50: 5.00E+4nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article