BDBM344051 US10370387, Example 35::US9777017, Example 35::US9908895, Example 35

SMILES CCc1nc2cnc3ccsc3c2n1[C@@H]1CC[C@@H](CC#N)[C@@H](O)C1

InChI Key InChIKey=VTRYKMIPNQEAPD-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 344051   

TargetTyrosine-protein kinase JAK1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM344051(US9777017, Example 35 | US9908895, Example 35 | US...)
Affinity DataIC50: 100nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM344051(US9777017, Example 35 | US9908895, Example 35 | US...)
Affinity DataIC50: 2.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2019
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM344051(US9777017, Example 35 | US9908895, Example 35 | US...)
Affinity DataIC50: 100nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2(Human)
Incyte Holdings

US Patent
LigandPNGBDBM344051(US9777017, Example 35 | US9908895, Example 35 | US...)
Affinity DataIC50: 2.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte Holdings

US Patent
LigandPNGBDBM344051(US9777017, Example 35 | US9908895, Example 35 | US...)
Affinity DataIC50: 100nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte Holdings

US Patent
LigandPNGBDBM344051(US9777017, Example 35 | US9908895, Example 35 | US...)
Affinity DataIC50: 2.00E+3nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2020
Entry Details
Go to US Patent