BDBM3436 6-(2,6-Dibromo-phenyl)-pyrido[2,3-d]pyrimidine-2,7-diamine::6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine::6-arylpyrido[2,3-d]pyrimidine deriv. 18::ACS Chem. Biol. Compound 1

SMILES Nc1ncc2cc(c(N)nc2n1)-c1c(Br)cccc1Br

InChI Key InChIKey=HGIPWJYTPOHUGK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 3436   

LigandPNGBDBM3436(6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-d...)
Affinity DataIC50: 5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
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LigandPNGBDBM3436(6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-d...)
Affinity DataIC50: 1.30E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM3436(6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-d...)
Affinity DataIC50: 1.60E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBiotin carboxylase(Escherichia coli (strain K12))
Pfizer

LigandPNGBDBM3436(6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-d...)
Affinity DataIC50: 1nMpH: 8.0 T: 2°CAssay Description:Assays were performed in 384-well clear bottom plates (Corning; catalog no. 3702), that contained inhibitor solvated in DMSO. To each well of the pla...More data for this Ligand-Target Pair
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TargetBiotin carboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
Achaogen

Curated by ChEMBL
LigandPNGBDBM3436(6-(2,6-dibromophenyl)pyrido[2,3-d]pyrimidine-2,7-d...)
Affinity DataIC50: 180nMAssay Description:Inhibition of recombinant N-terminal His-tagged Pseudomonas aeruginosa PAO1 biotin carboxylase expressed in Escherichia coli Rosetta(DE3) pLysS cells...More data for this Ligand-Target Pair
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PubMed