BDBM3433 1-[2-amino-6-(2,6-dimethylphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea::6-arylpyrido[2,3-d]pyrimidine deriv. 15::CHEMBL57323::PD089828 analog 15

SMILES Cc1cccc(C)c1-c1cc2cnc(N)nc2nc1NC(=O)NC(C)(C)C

InChI Key InChIKey=GQMZTFFTTCUZAW-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 3433   

LigandPNGBDBM3433(6-arylpyrido[2,3-d]pyrimidine deriv. 15 | CHEMBL57...)
Affinity DataIC50: 340nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
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PubMed
LigandPNGBDBM3433(6-arylpyrido[2,3-d]pyrimidine deriv. 15 | CHEMBL57...)
Affinity DataIC50: 400nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM3433(6-arylpyrido[2,3-d]pyrimidine deriv. 15 | CHEMBL57...)
Affinity DataIC50: 110nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM3433(6-arylpyrido[2,3-d]pyrimidine deriv. 15 | CHEMBL57...)
Affinity DataIC50: 340nMpH: 7.4 T: 2°CAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM3433(6-arylpyrido[2,3-d]pyrimidine deriv. 15 | CHEMBL57...)
Affinity DataIC50: 400nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article

LigandPNGBDBM3433(6-arylpyrido[2,3-d]pyrimidine deriv. 15 | CHEMBL57...)
Affinity DataIC50: 110nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
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TargetInsulin receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3433(6-arylpyrido[2,3-d]pyrimidine deriv. 15 | CHEMBL57...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of insulin receptor (InsR) tyrosine kinaseMore data for this Ligand-Target Pair
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PubMed
TargetEpidermal growth factor receptor(Human)
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM3433(6-arylpyrido[2,3-d]pyrimidine deriv. 15 | CHEMBL57...)
Affinity DataIC50: 610nMAssay Description:Inhibition of Epidermal growth factor receptor (EGFr) tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM3433(6-arylpyrido[2,3-d]pyrimidine deriv. 15 | CHEMBL57...)
Affinity DataIC50: 110nMAssay Description:Inhibition of C-src tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM3433(6-arylpyrido[2,3-d]pyrimidine deriv. 15 | CHEMBL57...)
Affinity DataIC50: 340nMAssay Description:The kinase activity is the enzyme activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] ATP to the poly (E: Y) substrate. N...More data for this Ligand-Target Pair
In DepthDetails Article