BDBM343035 1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-4-hydroxy-N-3-isoxazolyl-6-isoquinolinesulfonamide::US9776995, Example 17

SMILES COc1cc(c(Cl)cc1-c1ncc(O)c2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(F)c1

InChI Key InChIKey=HSCRCEFYDVLJFT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 343035   

LigandPNGBDBM343035(1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-4-hy...)
Affinity DataIC50: 85.1nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM343035(1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-4-hy...)
Affinity DataIC50: 1.00E+4nMAssay Description:293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM343035(1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-4-hy...)
Affinity DataIC50: 85nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM343035(1-(2-chloro-3'-fluoro-5-methoxy-4-biphenylyl)-4-hy...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed