BDBM342941 1-(2-cyano-5-methoxy-3'-(trifluoromethyl)-4-biphenylyl)-N-3-isoxazolyl-6-isoquinolinesulfonamide::US9776995, Example 148

SMILES COc1cc(-c2cccc(c2)C(F)(F)F)c(cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)C#N

InChI Key InChIKey=QNLZXVNVBXFIOQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 342941   

LigandPNGBDBM342941(1-(2-cyano-5-methoxy-3'-(trifluoromethyl)-4-biphen...)
Affinity DataIC50: 28.6nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM342941(1-(2-cyano-5-methoxy-3'-(trifluoromethyl)-4-biphen...)
Affinity DataIC50: 1.00E+4nMAssay Description:293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM342941(1-(2-cyano-5-methoxy-3'-(trifluoromethyl)-4-biphen...)
Affinity DataIC50: 28nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed