BDBM342904 1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphenylyl)-N-3-isoxazolyl-6-isoquinolinesulfonamide::US9776995, Example 115

SMILES COc1cc(c(F)cc1-c1nccc2cc(ccc12)S(=O)(=O)Nc1ccon1)-c1cccc(c1)C(F)(F)F

InChI Key InChIKey=HNKNKWOBIYGMKR-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 342904   

LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human Nav1.3 expressed in CHO cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human hERG by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human Nav1.7 at resting/closed state expressed in HEK293 cells at -140 mV holding potential by manual whole cell patch clamp electrophy...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 1A2(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 3A4(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 13.5nMAssay Description:HEK 293 cells stably transfected with human Nav1.7 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology sy...More data for this Ligand-Target Pair
In DepthDetails
US Patent

LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 36nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 17nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells assessed as reduction in peak inward current by ionworks quattro electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2C9(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 430nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK293T cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetCytochrome P450 2D6(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
LigandPNGBDBM342904(1-(2-fluoro-5-methoxy-3'-(trifluoromethyl)-4-biphe...)
Affinity DataIC50: 1.00E+4nMAssay Description:293 cells stably transfected with Nav 1.5 were recorded in whole cell voltage clamp mode with the PatchXpress automated electrophysiology system acco...More data for this Ligand-Target Pair
In DepthDetails
US Patent