BDBM34188 2-[4-(4-fluorophenyl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylacetic acid ethyl ester::2-[[4-(4-fluorophenyl)-6-(trifluoromethyl)-2-pyrimidinyl]sulfonyl]acetic acid ethyl ester::MLS000100272::SMR000082310::cid_2980973::ethyl 2-[4-(4-fluorophenyl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylacetate::ethyl 2-[4-(4-fluorophenyl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylethanoate::ethyl {[4-(4-fluorophenyl)-6-(trifluoromethyl)-2-pyrimidinyl]sulfonyl}acetate

SMILES CCOC(=O)CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccc(F)cc1

InChI Key InChIKey=YSZZSESTGDKXTF-UHFFFAOYSA-N

Data  15 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 34188   

TargetToll-like receptor 9(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 8.91E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2012
Entry Details
PCBioAssay
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of C-terminal GST-tagged Bfl-1 (unknown origin) incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetBcl-2-like protein 1(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) incubated for 5 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetApoptosis regulator Bcl-2(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST fused Bcl-2 (unknown origin) incubated for 5 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBcl-2-like protein 2(Human)
Tianjin University

Curated by ChEMBL
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST fused Bcl-w (unknown origin) incubated for 5 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST fused Mcl-1 (unknown origin) incubated for 5 min by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of GST-tagged Bfl-1 (unknown origin) incubated for 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of Bfl-1 (unknown origin) incubated in dark by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 1.44E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/4/2012
Entry Details
PCBioAssay
TargetBcl-2-related protein A1(Mouse)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 3.78E+3nMpH: 7.0 T: 2°CAssay Description:The aim is to identify chemical probes of Bfl-1 through a fluorescence polarization assay (FPA) using FITC-Bid BH3 peptide. 1) Dose-response curves c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2009
Entry Details
PCBioAssay
TargetProtein RecA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataEC50:  3.30E+3nMAssay Description:Keywords: GFP-RecA intein, protein splicing, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, whi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2011
Entry Details
PCBioAssay
TargetProtein RecA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataEC50:  6.04E+3nMAssay Description:Keywords: GFP, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, which interrupt the DnaB, RecA, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2011
Entry Details
PCBioAssay
TargetBcl-2-related protein A1(Mouse)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 1.46E+3nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetBcl-2-related protein A1(Mouse)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 3.41E+3nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetSteroidogenic factor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 8.95E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetIsoform 2 of Nuclear receptor ROR-alpha (Alpha-2)(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 6.51E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetBcl-2-related protein A1(Mouse)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34188(SMR000082310 | cid_2980973 | ethyl 2-[4-(4-fluorop...)
Affinity DataIC50: 2.16E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2011
Entry Details
PCBioAssay