BDBM34183 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylacetic acid ethyl ester::2-[[4-phenyl-6-(trifluoromethyl)-2-pyrimidinyl]sulfonyl]acetic acid ethyl ester::MLS000049112::SMR000074423::cid_1151859::ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylacetate::ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfonylethanoate::ethyl {[4-phenyl-6-(trifluoromethyl)-2-pyrimidinyl]sulfonyl}acetate

SMILES CCOC(=O)CS(=O)(=O)c1nc(cc(n1)C(F)(F)F)-c1ccccc1

InChI Key InChIKey=OKXFPZQLPGPFOM-UHFFFAOYSA-N

Data  10 IC50  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 34183   

TargetProtein RecA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataEC50:  4.15E+3nMAssay Description:Keywords: GFP-RecA intein, protein splicing, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, whi...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of C-terminal GST-tagged Bfl-1 (unknown origin) incubated for 2 hrs by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBcl-2-related protein A1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of C-terminal GST-tagged Bfl-1 (unknown origin) incubated for 2 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails
PubMed
TargetBeta-lactamase(Pseudomonas aeruginosa)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 1.92E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetToll-like receptor 9(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 1.06E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
Target60S ribosomal protein L19-A(Baker's yeast)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataEC50:  5.57E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetAmmonium transporter MEP2(Baker's yeast)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataEC50:  6.82E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetGeneral amino acid permease AGP1(Baker's yeast)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataEC50:  4.59E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetVacuolar aminopeptidase 1(Baker's yeast)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataEC50:  4.12E+4nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetBcl-2-related protein A1(Mouse)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 3.72E+3nMpH: 7.0 T: 2°CAssay Description:The aim is to identify chemical probes of Bfl-1 through a fluorescence polarization assay (FPA) using FITC-Bid BH3 peptide. 1) Dose-response curves c...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetBcl-2-like protein 11(Human)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataEC50: >3.50E+5nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetProtein RecA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataEC50:  5.95E+3nMAssay Description:Keywords: GFP, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, which interrupt the DnaB, RecA, a...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetGeneral amino acid permease AGP1(Baker's yeast)
Nmmlsc

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataEC50:  1.38E+3nMAssay Description:University of New Mexico Assay Overview: Assay Support: 1R03 MH086450-01 Project Title: Chemical Screen of TOR pathway GFP fusion proteins in S. ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetBcl-2-related protein A1(Mouse)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 1.18E+3nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetBcl-2-related protein A1(Mouse)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 4.63E+3nMAssay Description:Sanford-Burnham Center for Chemical Genomics (SBCCG) Sanford-Burnham Medical Research Institute (San Diego, CA) NIH Molecular Libraries Screening Cen...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetSteroidogenic factor 1(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 9.74E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetIsoform 2 of Nuclear receptor ROR-alpha (Alpha-2)(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 9.47E+3nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay
TargetBcl-2-related protein A1(Mouse)
Burnham Center For Chemical Genomics

Curated by PubChem BioAssay
LigandPNGBDBM34183(ethyl 2-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-y...)
Affinity DataIC50: 5.36E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails
PCBioAssay