BDBM338837 US9751886, Compound 2

SMILES C[C@]1(Cn2nncc2C(N)=N1)c1cc(NC(=O)c2ccc(cn2)C#N)ccc1F

InChI Key InChIKey=XIOGEDRAOXMYRT-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 338837   

TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338837(US9751886, Compound 2)
Affinity DataIC50: 1.78nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338837(US9751886, Compound 2)
Affinity DataIC50: 1.78nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay is an APP derived 13 amino acids peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetBeta-secretase 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338837(US9751886, Compound 2)
Affinity DataIC50: 5.37nMAssay Description:This assay is a Fluorescence Resonance Energy Transfer Assay (FRET) based assay. The substrate for this assay contains the Swedish Lys-Met/Asn-Leu mu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 1(Human)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM338837(US9751886, Compound 2)
Affinity DataIC50: 7.24E+3nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338837(US9751886, Compound 2)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of BACE1 in human SKNBE2 cells expressing wild type amyloid precursor protein (APP695) assessed as amyloid beta42 level incubated for 18 h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338837(US9751886, Compound 2)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of BACE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338837(US9751886, Compound 2)
Affinity DataIC50: 2nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/17/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338837(US9751886, Compound 2)
Affinity DataIC50: 1nMAssay Description:Inhibition of BACE1 (unknown origin) by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338837(US9751886, Compound 2)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM338837(US9751886, Compound 2)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of BACE2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed