BDBM335715 1-(sec-Butyl)-3-methyl-N-((1- methyl-3-oxo-2,3- dihydroisoquinolin-4-yl)methyl)- 6-(6-(piperazin-1-yl)pyridin-3-yl)- 1H-indole-4-carboxamide::US9738630, Example 10

SMILES CCC(C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCNCC1)C(=O)NCc1c2ccccc2c(C)[nH]c1=O

InChI Key InChIKey=VLCVYPKAIQLQEJ-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 335715   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM335715(US9738630, Example 10 | 1-(sec-Butyl)-3-methyl-N-(...)
Affinity DataEC50: <500nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of hitone methyl transferases can be readily tested by assays known to those sk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
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