BDBM335714 US9738630, Example 9::tert-Butyl 4-(5-(1-(sec-butyl)-3- methyl-4-(((1-methyl-3-oxo-2,3- dihydroisoquinolin-4-yl)methyl) carbamoyl)-1H-indol-6-yl)pyridin- 2-yl)piperazine-1-carboxylate

SMILES CCC(C)n1cc(C)c2c(cc(cc12)-c1ccc(nc1)N1CCN(CC1)C(=O)OC(C)(C)C)C(=O)NCc1c2ccccc2c(C)[nH]c1=O

InChI Key InChIKey=LTHICEHOVQKREU-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 335714   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM335714(US9738630, Example 9 | tert-Butyl 4-(5-(1-(sec-but...)
Affinity DataEC50: <5.00E+3nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of hitone methyl transferases can be readily tested by assays known to those sk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
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