BDBM335712 5-(Ethyl(tetrahydro-2H-pyran-4- yl)amino)-4-methyl-N-((1-methyl- 3-oxo-2,3,5,6,7,8- hexahydroisoquinolin-4- yl)methyl)-4'-(morpholinomethyl)- [1,1'-biphenyl]-3-carboxamide::US9738630, Example 7

SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3CCCCc3c(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1

InChI Key InChIKey=XZGRXFCVHBOVSL-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 335712   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM335712(US9738630, Example 7 | 5-(Ethyl(tetrahydro-2H-pyra...)
Affinity DataEC50: <500nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of hitone methyl transferases can be readily tested by assays known to those sk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM335712(US9738630, Example 7 | 5-(Ethyl(tetrahydro-2H-pyra...)
Affinity DataIC50: 27nMAssay Description:Inhibition of EZH2 Y641F mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM335712(US9738630, Example 7 | 5-(Ethyl(tetrahydro-2H-pyra...)
Affinity DataIC50: 14nMAssay Description:Inhibition of wild-type EZH2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed