BDBM335711 5-(Ethyl(tetrahydro-2H-pyran-4- yl)amino)-N-((5-fluoro-1-methyl- 3-oxo-2,3-dihydroisoquinolin-4- yl)methyl)-4-methyl-4'- (morpholinomethyl)-[1,1'- biphenyl]-3-carboxamide::US9738630, Example 6

SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c3c(F)cccc3c(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1

InChI Key InChIKey=CRTHUCSCSGYHAX-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 335711   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM335711(US9738630, Example 6 | 5-(Ethyl(tetrahydro-2H-pyra...)
Affinity DataEC50: <50nMAssay Description:The effectiveness of compounds of the present invention as inhibitors of hitone methyl transferases can be readily tested by assays known to those sk...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2019
Entry Details
Go to US Patent