BDBM335391 US10717738, Example 41::US9732085, 41::methyl[4-(2-{2-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidin-6-yl}-1H-imidazol-5-yl)phenyl]carbamate

SMILES COC(=O)Nc1ccc(cc1)-c1cnc([nH]1)C1CCc2nc(cc(=O)n12)-c1cc(Cl)ccc1-n1cnnn1

InChI Key InChIKey=LFISLASAJUWGIR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 335391   

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335391(US9732085, 41 | methyl[4-(2-{2-[5-chloro-2-(1H-tet...)
Affinity DataIC50: 6.5nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335391(US9732085, 41 | methyl[4-(2-{2-[5-chloro-2-(1H-tet...)
Affinity DataIC50: 6.5nMAssay Description:Human Factor XIa (Haematologic Technologies Inc.) activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetCoagulation factor XI(Human)
Ono Pharmaceutical

US Patent
LigandPNGBDBM335391(US9732085, 41 | methyl[4-(2-{2-[5-chloro-2-(1H-tet...)
Affinity DataIC50: 6.5nMAssay Description:Human Factor XIa activity was measured at an enzyme concentration of 0.1 U/mL in 150 mM NaCl, 5 mM KCl, 1 mg/mL PEG6000, 50 mM HEPES-NaOH (pH7.4) wit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2021
Entry Details
Go to US Patent