BDBM333465 N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(6-methyl- 6-azaspiro[2.5]octan-1- yl)ethoxy)quinazolin-6-yl]- acrylamide::US10507209, Compound 14::US9730934, Compound 14

SMILES CN1CCC2(CC2CCOc2cc3ncnc(Nc4ccc(F)c(Cl)c4)c3cc2NC(=O)C=C)CC1

InChI Key InChIKey=YAPFODKXVWEFPW-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 333465   

TargetEpidermal growth factor receptor(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333465(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(6-methy...)
Affinity DataIC50: 0.390nMAssay Description:Assay Procedures:The abbreviations used in the following assay have the following meanings:HEPES: hydroxyethyl piperazine ethanesulfonic acid;Brij-35...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333465(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(6-methy...)
Affinity DataIC50: 2.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333465(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(6-methy...)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2019
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333465(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(6-methy...)
Affinity DataIC50: 0.390nMAssay Description:Samples:Controls: Gefitinib, erlotinib hydrochloride, purchased from Anqing worldchem Co., LTD.; lapatinib ditosylate, purchased from Taizhou Xingche...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333465(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(6-methy...)
Affinity DataIC50: 2.60nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetReceptor tyrosine-protein kinase erbB-4(Human)
Xuanzhu Pharma

US Patent
LigandPNGBDBM333465(N-[4-(3-chloro-4- fluorophenylamino)-7-(2-(6-methy...)
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent